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UNIT-I
1) History of Genetics:
a. Pre-Mendelian concept (500 BC–1850 AD)
b. Mendelian Era (1850-1900)
c. Post Mendelian concept (1900 onwards)
2) Mendel’s principles and rediscovery:
a. Mendel’s laws of inheritance
b. Reasons of Mendel’s success
c. Mendelian deviation or exception
3) Cell Division:
a. Mitosis
b. Importance of mitosis
c. Stages of mitosis
d. Significance of meiosis
e. Stages of meiosis
4) Chromosome:
a. Morphology and chemical composition
b. Structure and function
c. Recent models of chromosomes structure
d. Special chromosomes and functions of special chromosomes
5) Chromosomal theory of inheritance:
a. Inheritance of quantitative and qualitative traits
b. Characters of quantitative and qualitative traits
c. Sex linked, sex limited and sex influenced inheritance
d. Sex determination and sex differentiation
UNIT-II
1) Multiple alleles:
a. Some classical examples of multiple allele
b. Characters of multiple allele
2) Cytoplasmic inheritance:
a. Definition and characteristics of cytoplasmic inheritance
b. Material effects
c. Inheritance of structure and patterns
d. Inheritance due to parasite, symbiont and viruses
e. Kappa particles in paramecium
3) Mutation:
a. History and characteristics of mutation
b. Classification of mutation
i) Spontaneous mutation
ii) Induced mutation
c. Molecular basis of mutation
d. Mutator and anti mutator genes, mutable genes, suppressor
e. Mechanism of suppressor mutation
4) Induction and detection of mutation:
a. Physical mutagens
b. Chemical mutagens
c. Detection of mutation
d. Applications of mutation
5) Linkage:
a. History of linkage
b. Types of linkage
c. Detection of linkage
i) Detection in test cross generation
ii) Detection in F2 generation
6) Crossing over:
a. Definition
b. Factors affecting recombination frequency
c. Cytological basis of crossing over
d. Crossing over in the four strand stage
e. Relationship between chiasma and crossing over
f. Molecular mechanisms of crossing over
g. Linkage maps and linkage groups
6) Gene interaction:
a. Types of gene interaction
b. Typical dihybrid ration and its modifications
c. Modification of gene interaction F2 ratios partial dominance at an inhibitory locus (7:6:3)
d. Additive gene action (1:4:6:4:1)
e. Dominance modification of duplicate genes (11:5)
f. Modifying gene
g. Dominance modification
h. Major and minor gene affecting character
i. Suppression of mutant allele
j. Molecular basis for gene interaction
7) Hardy-Weinberg law:
a. Gene frequency
b. Genotype frequency
c. Gene pool
d. Random union of gametes
e. Random mating among genotypes
f. Hardy-Weinberg equilibrium
g. Equilibrium for one gene with two alleles
h. Equilibrium for one gene with multiple alleles
i. Equilibrium for two genes
8) Quantative inheritance:
a. Multiple factor hypothesis
b. Transgressive segregation
c. effects of environment on qualitative traits
9) Genetic basis of evolution and origin of species:
a. Theories of evolution :
i) Lamarckism
ii) Darwinism
iii) Mutation theory
iv) Neo. Darwinism.
10) Introduction to human genetics:
a. man the organism,
b. Cytogenetics of man:
chromosome banding
chromosome aberration
Genetics studies
genetics diseases
blood groups
Disputed Parentages
